It is easy for a process supervision suite to know when a service that was up is now down: the long-lived process implementing the service is dead. The supervisor, running as the daemon's parent, is instantly notified via a SIGCHLD. When it happens, s6-supervise sends a 'd' event to its ./event fifodir, so every subscriber knows that the service is down. All is well.
It is much trickier for a process supervision suite to know when a service that was down is now up. The supervisor forks and execs the daemon, and knows when the exec has succeeded; but after that point, it's all up to the daemon itself. Some daemons do a lot of initialization work before they're actually ready to serve, and it is impossible for the supervisor to know exactly when the service is really ready. s6-supervise sends a 'u' event to its ./event fifodir when it successfully spawns the daemon, but any subscriber reacting to 'u' is subject to a race condition - the service provided by the daemon may not be ready yet.
Reliable startup notifications need support from the daemons themselves. Daemons should notify the outside world when the service they are providing is reliably up - because only they know when it is the case.
s6 provides two ways for daemons to perform startup notification.
The second method should really be implemented in every long-running program providing a service. When it is not the case, it's impossible to provide reliable startup notifications, and subscribers should then be content with the unreliable 'u' events provided by s6-supervise.